What does Axl stand for?
The word AXL, coming from the Greek word “anexelekto”, means uncontrolled. The protein encoded by the gene AXL, called AXL (UFO, ARK, Tyro7, or JTK11), is a member of the TAM family of receptor tyrosine kinases (RTKs). AXL is composed of an extracellular, transmembrane and intracellular domain [ 8 ].
Where is the AXL gene located?
The gene AXL, located at chromosome 19q13.2, was first identified in patients with chronic myeloid leukaemia (CML) [ 7 ]. The word AXL, coming from the Greek word “anexelekto”, means uncontrolled.
Is American Axle & Manufacturing Holdings a good company?
American Axle & Manufacturing Holdings, Inc. has technology development agreement with Suzhou Inovance Automotive Ltd. The company was founded in 1994 and is headquartered in Detroit, Michigan. American Axle & Manufacturing Holdings, Inc.’s ISS Governance QualityScore as of June 1, 2021 is 2.
Is the gene Axl a potential target for cancer treatment?
GAS6/AXL signalling functions as an important pathway driving cancer cell survival, proliferation, migration and invasion, which makes AXL a potential target in cancer treatment [ 5, 6 ]. The gene AXL, located at chromosome 19q13.2, was first identified in patients with chronic myeloid leukaemia (CML) [ 7 ].
“AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.” Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), ROLE IN MYELOID LEUKEMIA.
What is the history of American Axle?
The company was founded in 1994 and is headquartered in Detroit, Michigan. American Axle & Manufacturing Holdings, Inc.’s ISS Governance QualityScore as of June 1, 2021 is 2. The pillar scores are Audit: 2; Board: 4; Shareholder Rights: 3; Compensation: 1.