Why is raloxifene not used for breast cancer?

Why is raloxifene not used for breast cancer?

However, raloxifene has fewer serious side effects. Tamoxifen is the only option for premenopausal women who choose to pursue breast cancer prevention. At present, raloxifene is not used for breast cancer prevention in premenopausal women because of the lack of data regarding safety in this population.

Why is tamoxifen preferred over raloxifene?

This means that in raloxifene reduces risk of invasive breast cancer by about 38 percent compared to tamoxifen reducing breast cancer by about 50 percent over almost 7 years; or, raloxifene is about 76 percent as effective as tamoxifen in reducing risk for invasive breast cancer over almost 7 years.

Why do aromatase inhibitors cause osteoporosis?

—Estrogen regulates physiologic bone remodeling by suppressing osteoclast-mediated bone resorption. During aromatase inhibitor–associated or postmenopausal estrogen deficiency, bone resorption and osteoblast-mediated bone formation are imbalanced, leading to net bone loss.

Why you should not take tamoxifen?

Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones.

What is the difference between tamoxifen and raloxifene?

Tamoxifen is used mainly to treat hormone receptor-positive breast cancer (breast cancer with cells that have estrogen and/or progesterone receptors on them). Raloxifene is used mostly to prevent and treat osteoporosis (very weak bones) in post-menopausal women.

When is tamoxifen not recommended?

Most experts agree that tamoxifen and raloxifene should not be used to reduce breast cancer risk in women who: Have a higher risk of serious blood clots* Are pregnant or planning to become pregnant. Are breastfeeding.

What are the side effects of taking raloxifene?

What side effects can this medication cause?

• hot flashes (more common in the first 6 months of raloxifene therapy)
• leg cramps.
• swelling of the hands, feet, ankles, or lower legs.
• flu-like syndrome.
• joint pain.
• sweating.
• difficulty falling asleep or staying asleep.

Does tamoxifen cause osteoporosis?

Conclusions: Tamoxifen is not associated with an increased risk of osteoporosis and osteoporotic fracture in premenopausal breast cancer patients. Tailored screening strategies for breast cancer survivors with different osteoporosis risks are needed.

Does tamoxifen increase bone density?

Tamoxifen can increase bone density because of its estrogen agonist effects in the postmenopausal bone. The consequences of bone loss can be measured through bone mineral density (BMD) and fracture rate.

Who should not use raloxifene?

14 embolism) have been reported with EVISTA. Women who have or have had blood clots 15 in the legs, lungs, or eyes should not take EVISTA. 16 • Women who have had a heart attack or are at risk for a heart attack may have an 17 increased risk of dying from stroke when taking EVISTA. 1.

What are contraindications of raloxifene?

Contraindications to raloxifene include past medical history of deep venous thrombosis, renal vein thrombosis, pulmonary embolism, malignancy, active smoking, or any thrombophilia (factor V Leiden deficiency, prothrombin gene mutation G20210A, antiphospholipid syndrome, deficiency of antithrombin, protein c and s …

Does raloxifene increase bone density?

Raloxifene is used to help prevent and treat thinning of the bones (osteoporosis) only in postmenopausal women. It works like an estrogen to stop the bone loss that can develop in women after menopause, but it does not increase the bone density as much as daily 0.625 mg doses of conjugated estrogens.

How effective are raloxifene and tamoxifen for breast cancer?

The initial results of STAR showed that raloxifene and tamoxifen were equally effective in reducing invasive breast cancer risk in postmenopausal women at increased risk of the disease after an average of 47 months.

Are tamoxifen and raloxifene related to cataracts?

In the BCPT, women in the tamoxifen group had a 14 percent increased risk of developing a cataract. During STAR, 739 of 9,736 women in the tamoxifen group developed a cataract compared to 603 of 9,754 women in the raloxifene group.

Can tamoxifen be used to treat breast pain (mastalgia)?

Tamoxifen can be used off-label to treat breast pain (mastalgia), because it reduces estrogen levels that cause breast swelling.In one study, tamoxifen relieved pain in more than two-thirds of women who had a history of severe breast pain. Experts disagree about the use of tamoxifen for breast pain, because it has important side effects and risks.

Can tamoxifen or raloxifene cause blood clots?

Both tamoxifen and raloxifene are known to increase a woman’s chance of developing blood clots by up to three times that of women who are not taking either drug.