Table of Contents
- 1 Why is AUC important pharmacology?
- 2 What does AUC tell you about a drug?
- 3 What is AUC in clinical trials?
- 4 What does AUC value mean?
- 5 How is drug AUC calculated?
- 6 What does AUC stand for in toxicology?
- 7 How do you use AUC in clinical trials?
- 8 What is the trapezoidal rule for drug concentration and AUC?
Why is AUC important pharmacology?
The AUC (from zero to infinity) represents the total drug exposure across time. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure.
What does AUC tell you about a drug?
The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L. This area under the curve is dependant on the rate of elimination of the drug from the body and the dose administered.
What does AUC measure in pharmacology?
The AUC is a measure of total systemic exposure to the drug. AUC is one of several important pharmacokinetic terms that are used to describe and quantify aspects of the plasma concentration-time profile of an administered drug (and/or its metabolites, which may or may not be pharmacologically active themselves).
What is AUC in clinical trials?
The area under curve (AUC) is frequently used in clinical pharmacology to estimate the area inscribed by the plot of plasma, serum or whole blood drug levels versus time and can be interpreted as the total uptake or extent of exposure to drug.
What does AUC value mean?
AUC represents the probability that a random positive (green) example is positioned to the right of a random negative (red) example. AUC ranges in value from 0 to 1. A model whose predictions are 100\% wrong has an AUC of 0.0; one whose predictions are 100\% correct has an AUC of 1.0.
Why is area under the curve important?
Originally Answered: Why is it important to know the area of a curve in integral calculus? The area under a curve will indicate a number directly related to the data. Depending on the problem you are solving, it will be a solution to a question.
How is drug AUC calculated?
Starts here8:36How to calculate area under the curve (AUC) – YouTubeYouTube
What does AUC stand for in toxicology?
Area under the plasma concentration time curve (AUC) The area under the plasma (serum, or blood) concentration versus time curve (AUC) has an number of important uses in toxicology, biopharmaceutics and pharmacokinetics. Toxicology AUC can be used as a measure of drug exposure.
What is the AUC at steady state dosing interval?
During repeat-dose administration we often calculate the AUC during a steady state dosing interval (AUC 0-τ) as a measure of overall drug exposure. Interestingly, if clearance remains constant for a drug (no change in CL with increasing concentrations), AUC 0-τ at steady state will be identical to the AUC 0-∞ following single-dose administration.
How do you use AUC in clinical trials?
Using Area Under the Curve (AUC) as Clinical Endpoints. Area Under Curve (AUC) has been frequently used as the endpoint measure in clinical trials. We use AUC commonly in clinical pharmacology – Area under the time concentration curve or in diagnostic research – Area Under the ROC curve. The use of AUC is much more broader than what we think.
What is the trapezoidal rule for drug concentration and AUC?
In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. The AUC (from zero to infinity) represents the total drug exposure across time.