Can HIV cause avascular necrosis?

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Can HIV cause avascular necrosis?

Avascular necrosis (AVN) is an emerging complication of HIV infection. The incidence of AVN in HIV patients is greater than the general population. Although the incidence has increased in the HAART era, the aetiology remains unclear.

What diseases cause avascular necrosis?

Medical conditions associated with avascular necrosis include:

  • Pancreatitis.
  • Diabetes.
  • Gaucher’s disease.
  • HIV/AIDS.
  • Systemic lupus erythematosus.
  • Sickle cell anemia.

What is a protease inhibitor and how does it work?

‌Protease inhibitors, which figure among the key drugs used to treat HIV, work by binding to proteolytic enzymes (proteases). That blocks their ability to function. Protease inhibitors don’t cure HIV. But by blocking proteases, they can stop HIV from reproducing itself.

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Is Dolutegravir a protease inhibitor?

Official Answer. No, Triumeq is not a protease inhibitor. It is a combination integrase inhibitor (dolutegravir) and nucleoside reverse transcriptase inhibitor (abacavir / lamivudine) used in the treatment of people living with HIV.

Why is efavirenz better than dolutegravir?

The integrase inhibitor dolutegravir is being considered in several countries in sub-Saharan Africa instead of efavirenz for people initiating antiretroviral therapy (ART) because of superior tolerability and a lower risk of resistance emergence.

What is the side effect of dolutegravir?

Insomnia, dizziness, headache and other central nervous system side-effects are occurring more frequently with everyday use of dolutegravir than clinical trials had suggested, and are most likely to occur in women, people over 60 and people starting abacavir at the same time, a German research group told the …

What is AVN and how does it affect people with HIV?

AVN affects people with HIV at 58 times the rate seen in the general population and is associated, at least in part, with the chronic inflammation that accompanies long-term HIV infection. In the early stages of AVN, there may be few or no symptoms.

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What are the signs and symptoms of AVN?

In the early stages of AVN, there may be few or no symptoms. As the disease progresses, there can be a growing pain in the groin and hip. As AVN doesn’t appear on a typical X-ray, diagnosis can often difficult. In fact, it is often mistaken for a simple muscle pain or arthritis.

What are the symptoms of HIV in the leg?

Latesha Elopre, MD, is a board-certified internist specializing in HIV. She is an assistant professor of infectious diseases at the University of Alabama at Birmingham. The problem starts out innocuously enough with some vague discomfort in the leg, especially in the groin area. Later, the pain becomes more severe and starts to involve the hip.

How does HIV affect the risk of hip fracture?

As a result of this process, a person with HIV will typically experience aging-related conditions 10 to 15 years earlier than their non-infected counterparts. Among these aging-related conditions are bone and hip fractures typically seen in people 70 and over. Other risk factors can contribute to AVN in people with HIV, including:

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