Does multiple myeloma affect the heart?

Does multiple myeloma affect the heart?

Introduction. Common manifestations of multiple myeloma include osteolytic lesions, cytopenias, hypercalcemia, and renal insufficiency. Patients may also exhibit heart failure which is often associated with either past therapy or cardiac amyloidosis. A less recognized mechanism is high-output heart failure.

Does multiple myeloma affect blood pressure?

Hypertension is commonly reported in multiple myeloma (MM) patients and may be associated with older age, disease-related complications and consequences of MM treatments.

What are the symptoms of dying from myeloma?

But when you have late-stage multiple myeloma, your symptoms may show up as:

• Being sick to your stomach.
• Bone pain in your back or ribs.
• Bruising or bleeding easily.
• Feeling very tired.
• Fevers.
• Frequent infections that are hard to treat.
• Losing a lot of weight.
• Not feeling like eating.

Does multiple myeloma cause cardiac amyloidosis?

Cardiologist identification of patients with cardiac AL amyloidosis. AL amyloidosis may develop in patients with multiple myeloma (10\%–15\%) or may progress from monoclonal gammopathy of undetermined significance (MGUS) (9\%).

Can multiple myeloma cause atrial fibrillation?

Conclusions: AF is very frequent in patients with multiple myeloma when they receive ASCT. The presence of abnormal renal function, left ventricular systolic dysfunction, dilated left atrium, or hypertension at baseline identifies patients at high risk of developing AF following ASCT.

Why is calcium High in multiple myeloma?

Because myeloma patients often have irreversible impairment in renal function and increased renal tubular calcium reabsorption, the capacity of the kidneys to clear excess calcium load from the circulation effectively is overwhelmed, resulting in elevated serum calcium levels.

Which is worse multiple myeloma or amyloidosis?

The treatment of amyloidosis was demonstrated to be far more challenging than multiple myeloma because of the underlying organ damage, in particular, renal and cardiac dysfunction.

What are warning signs of multiple myeloma?

Exhaustion: unusual level of fatigue that fails to go away,even accompanied with a healthy diet and adequate rest.

Anemia: a critically low level of red blood cells in the body,which results in overwhelming fatigue.

Bone pain: bones thin and weak,resulting in mild/moderate pain around bones and occasionally osteoporosis.

How can multiple myeloma be diagnosed?

To diagnose or rule out multiple myeloma, your doctor may order blood tests to check for M proteins produced by plasma cells. This protein will be in your blood if you have the disease. Blood testing may also find beta-2 microglobulin, which is another abnormal protein. Your doctor can also order blood tests to check your:

Can you prevent multiple myeloma?

With multiple myeloma, few cases are linked to risk factors that can be avoided. There is no known way to prevent multiple myeloma from developing in those people with monoclonal gammopathy of undetermined significance or solitary plasmacytomas.

How can multiple myeloma be prevented?

If you’re at high risk for active multiple myeloma, your doctor may prescribe a chemotherapy drug, lenalidomide (Revlimid), and dexamethasone. These treatments may help you prevent complications and live longer. Immunotherapy. This new type of treatment for smoldering multiple myeloma is in clinical trials.