Table of Contents
- 1 How do you reduce hepatotoxicity?
- 2 Which TB drugs cause liver damage?
- 3 What does isoniazid do to the liver?
- 4 Can TB medication damage the liver?
- 5 How can I protect my liver during TB treatment?
- 6 Can tuberculosis be treated in patients with chronic liver disease?
- 7 How can I avoid complications from tuberculosis?
- 8 What are the treatment options for tuberculosis (TB)?
How do you reduce hepatotoxicity?
Treatments for toxic hepatitis may include:
- Supportive care. People with severe symptoms are likely to receive supportive therapy in the hospital, including intravenous fluids and medication to relieve nausea and vomiting.
- Medication to reverse liver damage caused by acetaminophen.
- Emergency care.
- Liver transplant.
Which TB drugs cause liver damage?
A combination of isoniazid (INH), rifampicin, pyrazinamide, and ethambutol is the commonly recommended treatment regimen for TB. However, drug-induced liver injury (DILI) is a major adverse event of anti-TB treatment, leading to nonadherence, treatment failure, or development of drug resistance.
How does isoniazid affect the liver?
Chronic INH hepatotoxicity results in the induction of hepatocyte apoptosis, with associated disruption of mitochondrial membrane potential and DNA strand breaks. The most likely biochemical mechanism is that the metabolism of INH produces reactive metabolites that bind and damage cellular macromolecules in the liver.
What does isoniazid do to the liver?
Even with monitoring, isoniazid remains a major cause of acute liver failure due to idiosyncratic reactions, and is associated with several instances of acute liver failure and death or emergency liver transplanation in the United States each year.
Can TB medication damage the liver?
Anti-tuberculosis treatment is known to cause liver damage in 4 percent to 11 percent of patients mandating to stop the treatment till the liver enzymes come to normal. In ~0.1 percent cases this could prove fatal.
How do you treat hepatotoxicity at home?
How to Treat Hepatitis A Symptoms at Home
- Stay in. Until any fever and jaundice have cleared up, your doctor will want you to skip work or school and stay at home.
- Rest up.
- Take care of your skin.
- Eat small meals.
- Get enough calories.
- Avoid alcohol.
- Go easy on your liver.
- Keep your illness to yourself.
How can I protect my liver during TB treatment?
Prophylactic therapy of silymarin is contributed to a noticeably reduced risk of development of anti-TB DILI four weeks after the initiation. In addition, silymarin significantly improved the liver function in patients who are receiving anti-TB drugs.
Can tuberculosis be treated in patients with chronic liver disease?
Treatment of tuberculosis in patients who already have a chronic liver disease poses various clinical challenges. There is an increased risk of drug induced hepatitis in these patients and its implications are potentially more serious in these patients as their hepatic reserve is already depleted.
How does tuberculosis affect the liver?
Liver disease can occur due to hepatic tuberculosis or the treatment with various anti-tubercular drugs may precipitate hepatic injury or patients with chronic liver disease may develop tuberculosis and pose special management problems. Tuberculosis per se can affect liver in three forms.
How can I avoid complications from tuberculosis?
Taking medication as directed, seeing your doctor for regular checkups, and practicing healthy lifestyle habits can help you avoid complications from TB. Taking medication as directed, seeing your doctor for regular checkups, and practicing healthy lifestyle habits can help you avoid complications from tuberculosis.
What are the treatment options for tuberculosis (TB)?
A standard treatment regime for latent TB is taking the antibacterial drug isoniazid for six to nine months. Treatment of active TB usually involves a combination of three or four drugs.