Table of Contents
How many amino acids will be produced by the normal DNA mRNA sequence?
There are 64 possible codons, three of which do not code for amino acids but indicate the end of a protein. The remaining 61 codons specify the 20 amino acids that make up proteins. The AUG codon, in addition to coding for methionine, is found at the beginning of every mRNA and indicates the start of a protein.
How many nucleotides are present in the normal DNA sequence Model 1?
DNA molecules are composed of four nucleotides, and these nucleotides are linked together much like the words in a sentence. Together, all of the DNA “sentences” within a cell contain the instructions for building the proteins and other molecules that the cell needs to carry out its daily work.
What is the result of this substitution mutation on the amino acid sequence?
A substitution mutation can cause the following: Change in the coding of amino acids codon to a particular stop codon resulting in an incomplete protein, which is usually non-functional. Can cause Silent mutations where a codon change can encode the same amino acid resulting in no changes in the protein synthesized.
What is the effect of the deletion mutation on the amino acid sequence as it is compared to the normal amino acid sequence?
1). Because an insertion or deletion results in a frame-shift that changes the reading of subsequent codons and, therefore, alters the entire amino acid sequence that follows the mutation, insertions and deletions are usually more harmful than a substitution in which only a single amino acid is altered.
How many mRNA nucleotides are required to encode this polypeptide?
The human β-globin polypeptide contains 146 amino acids. How many mRNA nucleotides are required to encode this polypeptide? Note: (146*3)=438 because 3 nucleotides make up 1 codon, which codes for the amino acid.
Do all substitutions cause a change in the amino acid sequence of a protein?
Depending on the number of amino acids affected and their positions within the polypeptide chain, the protein may or may not function properly. However, base substitutions do not always cause a change in the sequence of amino acids.
How does a substitution mutation affect the DNA sequence?
With base substitution mutations, only a single nucleotide within a gene sequence is changed, so only one codon is affected (Figure 1). Figure 1: Only a single codon in the gene sequence is changed in base substitution mutation.
Which sequence of amino acids could there be in the first six amino acids of the sickle cell β hemoglobin HBS chain?
The first six of these amino acids are: valine, histidine, leucine, threonine, proline , and glutamic acid. The specific base sequence for these amino acids is: GTG/CAC/CTG/ACT/CCT/GAG.