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Is BCL-2 an oncogene or tumor suppressor?
Apoptosis-Suppressing Oncoprotein Bcl-2 Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.
What is the role of BCL-2 in apoptosis?
BCL2 prevents BAX/BAK oligomerization, which would otherwise lead to the release of several apoptogenic molecules from the mitochondrion. It is also known that BCL2 binds to and inactivates BAX and other pro-apoptotic proteins, thereby inhibiting apoptosis.
Is BCL-2 a tumor suppressor?
Beclin 1 has been touted as a tumor suppressor gene, becoming haploinsufficient in some types of human cancers (Aita et al., 1999; Liang et al., 1999). Interestingly, protein-targeting studies suggest that the anti-autophagic function of Bcl-2 is conveyed from the ER (Pattingre et al., 2005).
Why is BCL-2 an oncogene?
The bcl-2 oncogene is activated as a consequence of the t(14;18) chromosomal translocation in human follicular lymphomas. Bcl-2 functions to inhibit apoptosis in a variety of in vitro and in vivo experiments, suggesting interference with a central mechanism of apoptosis.
What is a BCL2 inhibitor?
Targeting BCL2 with the BH3-mimetic, venetoclax. Venetoclax and CLL. Venetoclax and AML. BCL2 inhibition in other hematological malignancies. Lessons from clinical experience with venetoclax to date.
What chromosome is BCL2 on?
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas.
What does BCL stand for in biology?
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism.
Does Bcl-2 prevent apoptosis?
Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death. Apoptosis.
What are Bcl-2 inhibitors?
A selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2 inhibitor BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells.
What are BCL2 inhibitors?
What is the function of BCL-2?
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis.
How do BCL-2 inhibitors work?
Most anti-cancer agents, including kinase inhibitors, induce apoptosis in cells that are dependent on a pathway targeted by the inhibitor. When a cancer cell is treated with a targeted agent, early changes in the BCL-2 family of proteins can be rapidly detected preceding the activation of apoptosis.