Is metabolism the same as elimination?

Is metabolism the same as elimination?

Distribution is a reversible process of movement of drugs from and to the site of measurement, typically the plasma or blood. Elimination comprises metabolism and excretion, and represents the total irreversible loss of the drug from the body.

What is the difference between drug elimination and excretion?

Drugs are removed from the body by various elimination processes. Drug elimination refers to the irreversible removal of drug from the body by all routes of elimination. Drug excretion is the removal of the intact drug.

What do you mean by drug metabolism?

Drug metabolism is the term used to describe the biotransformation of pharmaceutical substances in the body so that they can be eliminated more easily. The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there.

What do you understand by metabolism and excretion of drugs?

Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization; whatever the process, the goal is to make the drug easier to excrete. The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver.

Where does drug metabolism mainly take place?

The liver is the principal site of drug metabolism (for review, see [1. Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active—sometimes even more… read more ]).

What is the use of metabolism?

Metabolism is the process by which your body converts what you eat and drink into energy. During this complex process, calories in food and beverages are combined with oxygen to release the energy your body needs to function.

Where are drugs excreted?

Most drugs, particularly water-soluble drugs and their metabolites, are eliminated largely by the kidneys in urine. Therefore, drug dosing depends largely on kidney function. Some drugs are eliminated by excretion in the bile (a greenish yellow fluid secreted by the liver and stored in the gallbladder).

What factors affect metabolism of a drug?

Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism). For many drugs, metabolism occurs in 2 phases.

What are the two phases of drug metabolism?

Metabolism is often divided into two phases of biochemical reaction – phase 1 and phase 2. Some drugs may undergo just phase 1 or just phase 2 metabolism, but more often, the drug will undergo phase 1 and then phase 2 sequentially.

What is the most common means of drug elimination through excretion?

Renal excretion is the most common route of drug elimination. However, many drugs are excreted into bile via the liver and some volatile substances (primarily gaseous anesthetics) can be excreted via the lungs.

What are the 2 phases of drug metabolism?

Classically, drug metabolism is divided into two general components, designated as phase I and phase II reactions.

What are the 3 types of metabolism?

There are three basic metabolism types: ectomorph, mesomorph, and endomorph – definitely words you probably don’t use in your normal, day-to-day conversations. But learning the types of body you were born with will help your fitness plan in the long run.