Should I be concerned if my alkaline phosphatase is high?

Should I be concerned if my alkaline phosphatase is high?

High alkaline phosphatase levels may mean there is damage to your liver or that you have a type of bone disorder. Liver damage creates a different type of ALP than bone disorders do.

What infections cause high alkaline phosphatase?

Extremely high elevations of alkaline phosphatase are most frequently seen in patients with sepsis, malignant obstruction, and AIDS. Patients with sepsis can have an extremely high alkaline phosphatase level and a normal bilirubin.

What causes sudden increase in alkaline phosphatase?

High ALP levels can be caused by bone diseases, such as Paget’s disease, osteomalacia, rickets, bone tumors, or tumors that have spread from another part of the body to the bone, or by overactive parathyroid glands (hyperparathyroidism). Normal healing of a bone fracture can also raise ALP levels.

Does high alkaline phosphatase mean cancer?

An increased ALP is a common laboratory finding in colon cancer, especially with liver metastasis. We found that serum ALP levels are significantly different among patients with and without a liver metastasis. This finding is consistent among levels at the time of diagnosis as well as the final levels.

Can fatty liver cause high alkaline phosphatase?

Fatty liver linked to obesity often causes a rise in liver transaminases but not a solitary rise in alkaline phosphatase. Bone pathology causes of elevated alkaline phosphatase include Paget’s disease, hyperparathyroidism, osteomalacia, metastatic bone disease and a recent fracture.

Can arthritis cause elevated alkaline phosphatase?

Increased concentration of serum alkaline phosphatase (ALP) is a common feature in rheumatoid arthritis (RA), although its origin remains unclear. The aim of this study is to analyze the origin and clinical significance of the elevated ALP value in RA.

What bone disorders cause elevated alkaline phosphatase?

Bone pathology causes of elevated alkaline phosphatase include Paget’s disease, hyperparathyroidism, osteomalacia, metastatic bone disease and a recent fracture.

Can low vitamin D cause high alkaline phosphatase?

Elevated serum alkaline phosphatase (ALP) level is an essential marker for the diagnosis of vitamin D deficiency (1). Some cases of vitamin D deficiency are diagnosed accidentally on the basis of elevated ALP levels.

What cancers cause elevated alkaline phosphatase?

Serum ALP levels are elevated in patients with primary and metastatic tumors of the liver and bone, such as hepatic metastasis of colorectal cancer and bone and liver involvement in breast cancer. [1,4] In patients with malignancies, therefore, an elevated serum ALP may be an indicator of metastatic disease.

Does vitamin D affect alkaline phosphatase?

The correlation coefficient of alkaline phosphatase and serum vitamin D3 levels was r =0.05 (p =0.593). Conclusion: Serum vitamin D3 levels may not be correlated with increased serum alkaline phosphatase levels. Therefore, alkaline phosphatase may not be used as a screening test to rule out vitamin D deficiency.

What cancers cause high ALP?

Background: Alkaline phosphatase (ALP) is an enzyme that is elevated by various hepatobiliary diseases. Generally its elevation is thought to indicate bile stasis. There are some reports that show ALP is an important prognostic factor for several cancers such as colon, lung, and gastric cancer.

Is alkaline phosphatase elevated in pancreatic cancer?

Laboratory studies in patients with cancer of the head of the pancreas typically reveal elevated levels of serum total bilirubin, alkaline phosphatase, γ-glutamyl transpeptidase, and the hepatic aminotransferases.