Table of Contents
What does the Wobble Hypothesis state?
The wobble hypothesis states that the base at 5′ end of the anticodon is not. spatially confined as the other two bases allowing it to form hydrogen bonds. with any of several bases located at the 3′ end of a codon.
Why is wobbling allowed only for the 3rd base of a codon?
There are more than one codon for one amino acid. According to this hypothesis, only the first two bases of the codon have a precise pairing with the bases of the anticodon of tRNA, while the pairing between the third bases of codon and anticodon may Wobble (wobble means to sway or move unsteadily).
What is a wobble codon?
The wobble position of a codon refers to the 3rd nucleotide in a codon. This nucleotide has two major characteristics: Binding of a codon in an mRNA the cognate tRNA is much “looser” in the third position of the codon. This permits several types of non-Watson–Crick base pairing to occur at the third codon position.
What are the wobble rules?
The rules of wobble pairing ensure that a tRNA does not bind to the wrong codon. The tRNA for phenylalanine has an anticodon of 3′-AAG-5′, which can pair with two codons for phenylalanine (described above), but not with 5′-UUA-3′ or 5′-UUG-3′ codons.
Which base of a codon is called wobble base?
A wobble base pair is a pairing between two nucleotides in RNA molecules that does not follow Watson-Crick base pair rules. The four main wobble base pairs are guanine-uracil (G-U), hypoxanthine-uracil (I-U), hypoxanthine-adenine (I-A), and hypoxanthine-cytosine (I-C).
Who explained the wobble hypothesis Mcq?
Francis Crick
Explanation: In 1966, Francis Crick devised the wobble hypothesis to explain the observations regarding base pairing. It states that the base at the 5′ end of the anticodon is not as spatially confined as the other two, allowing it to form hydrogen bonds with any of the several bases located at the 3′ end of a codon.
Why are wobble base pairs less stable?
This fact implies that each tRNA anticodon must wobble with one or more nucleotides to recognize all codons in a synonymous codon family [3]. A wobble base-pair is a non-Watson-Crick base pairing between two nucleotides in RNA molecules and hence it is less stable than a Watson-Crick base pairing.
What is wobble effect or phenomenon?
The wobble hypothesis deals with the phenomenon of degeneracy that is seen in the genetic code through tRNA recognition of more than one codon. Each tRNA contains a triplet anti-codon that is complementary to a codon in mRNA.
Who explained the Wobble Hypothesis Mcq?
Which codon and anti codon is involved in wobble?
“Wobble” Pairing of the tRNA anticodon with the mRNA codon proceeds from the 5′ end of the codon. In this example, the double-ringed G can pair with either a single-ringed U or C.
Which position of a codon is said to wobble First Second Third Fourth?
Which position of a codon is said to wobble? Explanation: The third position in each codon is much less specific than the first and second and is said to wobble. 6.
Where does the wobble occur in the anticodon of tRNA?
The wobble occurs only in the third base of the anticodon. c. When inosine (I) is the first nucleotide of an anticodon, at least three different codons for the same amino acid can be recognized. d. tRNA molecules can recognize codons that specify two different amino acids. c.
What is the frequency of occurrence of all A2C codons?
So the frequency of occurrence of all the A 2 C codons is 3 x 0.116. Normalizing to AAA having a relative frequency of 1.0, the frequency of A 2 C codons is 3 x (0.116/0.578) = 3 x 0.2.
What are the nucleotide positions of the codon and the anticodon?
The nucleotide positions of the codon and the anticodon are numbered 1, 2, and 3 in the 5′ to 3′ direction. What fundamental principle of nucleic acid interactions is manifest by the observation that anticodon nucleotide 3 base pairs with codon nucleotide 1?
How many codons are in a bacterial mRNA of 800 nucleotides?
A bacterial mRNA of 800 nucleotides could code for a 300 amino acid protein. b. There are at least three codons for each amino acid. c. A new codon begins every three nucleotides. d. The fourth codon establishes the reading frame. c. A new codon begins every three nucleotides.