Table of Contents
What is ARV 7?
ARv7 is a constitutively active AR splice variant and is a difficult to detect diagnostic prostate cancer biomarker that is associated with resistance to second generation therapies.
What is ARv7 prostate cancer?
The AR-V7 Nucleus Detect® test is a simple blood test for patients with metastatic castration-resistant prostate cancer (mCRPC) who have failed an androgen receptor (AR)–targeted therapy.
What company makes xtandi?
XTANDI® (enzalutamide) Approved by U.S. FDA for the Treatment of Metastatic Castration-Sensitive Prostate Cancer | Pfizer.
What does abiraterone therapy do?
It is usually only offered to men whose cancer has stopped responding to other types of hormone therapy – you may hear this called second-line therapy. But some men might be offered abiraterone as a first treatment for advanced prostate cancer.
How common is AR V7?
A share of 53.1\% (17/32) of CRPC patients had detectable AR-V7 (range 0–146 copies/mL blood), while AR-V7 was also identified in 4 HSPC patient CTC samples, at generally lower levels (range 0–4 copies/mL blood).
How long can you stay on Xtandi?
How long does Xtandi extend life? In the AFFIRM trial, treatment with Xtandi extended life by almost 5 months. Treatment with Xtandi resulted in a median overall survival time of 18.4 months (95\% CI 17.3 to not yet reached) compared with 13.6 months (95\% CI 11.3 to 15.8) in the placebo recipients (p<0.001).
Is Xtandi an ADT?
A new study has found that enzalutamide (Xtandi) given with androgen deprivation therapy (ADT) significantly reduced the risk of metastatic progression or death in men with metastatic hormone-sensitive prostate cancer (mHSPC) versus placebo plus ADT, including patients with low-volume disease and/or prior docetaxel …
How long can you stay on abiraterone?
Life expectancy: The studies show that abiraterone acetate can prolong life. In the larger study, about 50 out of 100 men who had the standard treatment were still alive after 3 years, while after the same period of time 70 out of 100 men who had treatment with abiraterone acetate were still alive.
How effective is abiraterone?
Expert opinion: Abiraterone is highly effective and has an excellent safety profile for the treatment of metastatic castrate-naïve prostate cancer. It is the authors’ opinion that it should now be considered the new standard of care.
What happens when you stop taking Xtandi?
If your doctor thinks Xtandi has stopped working they will advise you to stop taking it. In about 50 percent of the men whose PSA level starts to rise again while on antiandrogen therapy, stopping treatment will lead to antiandrogen withdrawal syndrome or antiandrogen withdrawal response (AAWR).
What is the best time of day to take Xtandi?
Enzalutamide is given as a capsule or tablet taken once a day, preferably at the same time each day, with or without food. Take the capsules or tablets whole. Do not break, open, or chew them. If you miss a dose at your regular dose time, take it as soon as you remember that day.
Is Xtandi a chemo drug?
Dr. Graff: Zytiga (abiraterone) and Xtandi (enzalutamide) are similar to chemo in that, initially, they were used at the very end of the disease. Now they can be used up front when people are diagnosed with metastatic prostate cancer, so it depends.