Table of Contents
What is considered a high level of ANA?
A ratio of 1:640 or greater indicates a high possibility of autoimmune disorder, but results will need to be analyzed by a doctor and additional tests performed to draw a conclusion.
What does an ANA titer of 1 40 mean?
An ANA titer of 1:40 or higher is considered positive. An ANA titer of less than 1:40 is useful for ruling out SLE in children (sensitivity of 98\%). A repeated negative result makes a diagnosis of SLE unlikely but not impossible. The ANA titer does not correlate with the severity of the disease.
How common is a positive ANA test?
This standardization makes the ANA test very sensitive for the diagnosis of autoimmune diseases but results in many false positive results. At a dilution of 1:160, only 5 percent of normal individuals have a positive test for ANA.
What does ANA titer of 1 2560 mean?
The lowest dilution is 1:2560. When antibodies are present at the lowest dilution, this indicates that there is a very high number of antibodies in the blood, and that the body has mounted a substantial immune response against nuclear proteins. Result 2: the pattern.
What does ANA titer 1 1280 mean?
A high titer (1:1280 is high) is more likely to be associated with autoimmune diseases. Rheumatologists will usually try to get more information, using specific tests in people with such high titers, looking for lupus or rheumatoid arthritis, and it sounds like yours did so and got negative results, which is good news.
Is a ANA titer of 1 1280 high?
What is the Ana 12 Plus profile?
RDL’s ANA 12 Plus Profile Helps Differentiate Between 8 Autoimmune Disease States: This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
What does a high Ana titre mean?
These children tend to have higher ANA titres of > or =1:160. However, a positive ANA profile was strongly correlated with an ANA titre > or =1:640 and highly indicative of an autoimmune disorder (100\%).
What does a positive ANA test result mean?
A positive ANA profile correlated strongly with an ANA titre > or = 1:640 (chi2 = 5.7 , P<0.02). The study demonstrated that only 55\% of children with a positive ANA test had a definitive diagnosis of autoimmune disorder.
What happens if the Ana titer is negative?
If the ANA titer is negative, no further tests are performed except for Anti-Ro Ab. Anti-Ro is performed to find the very small percentage of false negative ANAs. If the ANA titer is positive, the complete profile is performed. The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells.