What is the best treatment for aplastic anemia?

What is the best treatment for aplastic anemia?

A bone marrow transplant is the only cure for aplastic anemia. Bone marrow transplants are also called stem cell transplants. A transplant is the preferred treatment for severe aplastic anemia. Bone marrow transplants replace damaged stem cells with healthy ones.

What immunosuppressants are used for aplastic anemia?

Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine A (CsA) is the first-line therapy for acquired aplastic anemia (AA) in those not suitable for bone marrow transplant. Horse ATG (hATG) is preferred for this purpose, but its use is often impeded by shortages and costs.

How effective is ATG?

Immunosuppression with anti-thymocyte globulin (ATG) was introduced in 1977. Subsequent trials confirmed the effectiveness of this form of treatment. Overall, between 75\% and 80\% of the patients achieve remission, defined as freedom from transfusion, following a first course of treatment with ATG.

Does aplastic anemia go away?

How Is It Treated? If your doctor can identify the cause of your aplastic anemia and get rid of that trigger, the condition may go away. But doctors can rarely pinpoint the exact cause. If your case isn’t severe, you may not need treatment unless or until your blood count drops below a certain level.

Can aplastic anemia come back?

Aplastic anemia is a serious illness. Treatment often depends on the underlying cause. For certain causes, you may recover after treatment. But the condition can come back.

What is ATG medication?

Introduction. Antithymocyte globulin (ATG) is an antibody preparation derived from rabbits or horses hyperimmunized with human thymocytes, which is used to prevent or treat acute cellular rejection after solid organ transplantation and as a therapy of acute aplastic anemia.

What is ATG procedure?

Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia.

Can you live a normal life with aplastic anemia?

Aplastic anemia is a life-threatening condition with very high death rates (about 70\% within 1 year) if untreated. The overall five-year survival rate is about 80\% for patients under age 20. In recent years, the long-term outcomes of aplastic anemia patients have been continuously improving.

Is aplastic Anaemia curable?

Although not a cure for aplastic anemia, blood transfusions can control bleeding and relieve symptoms by providing blood cells your bone marrow isn’t producing.

What is ATG made of?

Background. Antithymocyte globulin is a hyperimmune globulin preparation made from plasma of rabbits or horses that have been immunized with human thymocytes or T cells. ATG is given by infusion only and leads to a rapid decrease in circulating T cells.

Can aplastic anemia Be Cured?

Blood and bone marrow stem-cell transplants If a matched donor isn’t found in your family, your doctor will search the National Marrow Donor Program , which has millions of potential donors. Stem-cell transplant is the only possible cure for aplastic anemia.

Can ATG be given peripherally?

No phlebitis or symptomatic venous thrombosis occurred in any patients. Conclusions: Equine ATG can be safely administered via peripheral vein infusion. Its use does not require continued hospitalization or placement of a central line. Peripheral vein infusion is safe, convenient, and economical.

How effective is ATG for the treatment of aplastic anemia?

When used alone, ATG improves blood counts for aplastic anemia patients about half of the time. When used with cyclosporine, ATG improves blood counts in about 7 out of 10 cases.

What is ATG used for in bone marrow failure?

ATG may be used to treat other bone marrow failure diseases in some cases. ATG is approved by the U.S. Food and Drug Administration (FDA) for treating moderate and severe aplastic anemia. ATG is commonly used with another drug called cyclosporine.

What is antithymocyte globulin (ATG)?

Antithymocyte Globulin. This allows the bone marrow to grow and make new blood cells. ATG may be used to treat other bone marrow failure diseases in some cases. ATG is approved by the U.S. Food and Drug Administration (FDA) for treating moderate and severe aplastic anemia. ATG is commonly used with another drug called cyclosporine.

What is ATG used to treat?

ATG is approved by the U.S. Food and Drug Administration (FDA) for treating moderate and severe aplastic anemia. ATG is commonly used with another drug called cyclosporine. AAMDSIF does not recommend, endorse, or make any representation about the efficacy, appropriateness or suitability of any drug, treatment or therapy listed on this website.