Table of Contents
What is the other name of slugging method?
This step is called precompression (slugging) and the compacts made in the process (typically 25 mm diameter by about 10–15 mm thick) are termed slugs. Compression of mixed powders into slugs can be achieved either by slugging technique or roller compaction.
Which equipment is used in slugging method of granulation?
The original method of dry granulation employed a heavy duty tablet press to compact the dry powder. The compacting process in this case is known as slugging and the compacted material was therefore in the form of “slugs” – typically 25 mm in diameter and 10-15 mm thick.
Why do we granulate?
Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress.
What is the principle of granulation?
Granulation is a process in which powder particles are made to adhere to each other, resulting in larger, multi-particle entities, so called granules. If such a process is performed without adding liquids, this is called dry granulation.
Why is dry granulation preferred?
Dry granulation is by far the better process because today’s roller compactors enable you to produce consistently higher-quality granules at a higher output capacity. In comparison, wet granulation produces granules by cementing particles together using a liquid solution.
What is wet and dry granulation?
Granulation is the process of producing grains or granules. The main difference between dry and wet granulation is that dry granulation is the formation of granules without using any liquid solution whereas wet granulation is the formation of granules by adding a granulating liquid.
Why slugging is done?
Slugging is a pre-compression process for the formation of extra large tablets (slugs), usually of variable weight, due to poor flow of the drug powder. The procedure is applicable to the dry granulation of hydrolysable drugs, such as aspirin, which are not amenable to wet granulation.
Why dry granulation is done?
Within the pharmaceutical industry, the dry granulation process is primarily used to increase material flowability and prevent particle segregation, facilitating faster and more consistent feeding into the tableting process.
What is kneading in RMG?
RMG Chopper speed: Chopper is usually started after the fluid addition is complete. This will provide kneading energy to the granulation. The chopper use to reduce lumps of the granulated wet mass. The chopper blades rotating at high speeds fragment the dense mass into smaller granules.
What is granulating fluid?
The granulation liquid (fluid) contains a solvent or carrier material which must be volatile so that it can be removed by drying, and depending on the intended application, be non-toxic. Typical liquids include water, ethanol and isopropanol either alone or in combination.
What is slugging in dry granulation?
What is capping and lamination?
Capping and lamination Capping happens when the upper or lower part of a tablet separates horizontally (photo) as the press ejects the tablet. Lamination is separation that occurs at any other part of the tablet except the top or bottom.