Table of Contents
What is the role of MCP-1?
Monocyte chemoattractant protein-1 (MCP-1) is the most important chemokine that regulates migration and infiltration of monocytes/macrophages. MCP-1 is highly expressed in atherosclerotic plaques in response to cytokines, growth factors, oxLDL, and CD40L.
What type of cytokine is MCP-1?
The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family.
Is MCP-1 pro or anti inflammatory?
We hypothesized that intestinal macrophages recruited by MCP-1 play a role in reducing inflammation via the production of anti-inflammatory cytokines, such as IL-10, because intestinal macrophages produce large amounts of IL-10.
What is MCP in blood?
Monocyte chemotactic protein-1 (MCP-1) is a potent and specific activator of monocytes and basophils and causes migration of monocytes in vitro. 12, 13 It is produced by a number of cell types found within the resolving thrombus, for example, fibroblasts, smooth muscle cells, endothelial cells, and monocytes.
Where is MCP-1 produced?
macrophages
MCP-1 is encoded by the ccl2 gene and is produced in several cell types, including macrophages and fibroblasts20. Stimulation can occur directly through activation of pattern recognition receptors (PRR) and/or by cytokines such as, inter alia, IFNβ, IL-6 and TNFα21,22,23,24,25.
Is MCP-1 a proinflammatory cytokine?
MCP-1 plays a clear proinflammatory role in skeletal muscle, since specific muscular overexpression of MCP-1 in mice increases the expression of IL-1β and the macrophage markers F4/80 and CD68 in the gastrocnemius muscle [42].
Is MCP-1 an adhesion molecule?
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature.
How is MCP-1 produced?
MCP-1 is encoded by the ccl2 gene and is produced in several cell types, including macrophages and fibroblasts20. Stimulation can occur directly through activation of pattern recognition receptors (PRR) and/or by cytokines such as, inter alia, IFNβ, IL-6 and TNFα21,22,23,24,25.
What is a monocyte chemoattractant protein?
Monocyte chemoattractant protein 1 (MCP-1/CCL2) is one of the important chemokines from the CC family that controls migration and infiltration of monocytes/macrophages during inflammation. CCL2 is profoundly expressed in osteoporotic bone and prostate cancer-induced bone resorption.
What does MCP-1 stand for?
The monocyte chemoattractant protein-1 (MCP-1/CCL2) is a member of the C-C chemokine family, and a potent chemotactic factor for monocytes. MCP-1 is believed to be identical to JE, a gene whose expression is induced in mouse fibroblasts by platelet-derived growth factor (Cochran and others 1983).
How many amino acids are in MCP-1?
Located on chromosome 17 (chr.17, q11.2), human MCP-1 is composed of 76 amino acids and is 13 kDa in size (Van Coillie and others 1999). MCP belongs to a family composed of at least four members (MCP-1, −2, −3, and −4).
What is the Massachusetts contingency plan MCP?
Massachusetts Contingency Plan MCP Metacarpophalangeal (joint) MCP Multi-Core Processor MCP Media and Communications Processor (NVIDIA nForce) MCP Microchannel Plate MCP Modified Citrus Pectin (antiadhesive agent)