What makes up the blood-brain barrier?
Composition of the Blood-Brain Barrier The blood-brain barrier is a multicellular, compound structure composed of endothelial cells, pericytes and astrocytes in direct contact with brain tissue. The BBB is a compound structure following the brain’s labyrinth of vasculature.
What cells are involved in the blood-brain barrier?
The blood-brain barrier (BBB) is a diffusion barrier, which impedes influx of most compounds from blood to brain. Three cellular elements of the brain microvasculature compose the BBB-endothelial cells, astrocyte end-feet, and pericytes (PCs).
Where is the meninges located in the brain?
Brain meninges are three-layer tissue envelopes that have a protective, supportive and metabolic role. They are located between the brain and the skull and between the spinal cord and spinal vertebrae and are constructed of loose and dense connective tissues.
Is the meninges part of the brain?
Three layers of membranes known as meninges protect the brain and spinal cord. The delicate inner layer is the pia mater. The middle layer is the arachnoid, a web-like structure filled with fluid that cushions the brain. The tough outer layer is called the dura mater.
Who makes blood-brain barrier?
The blood–brain barrier is formed by endothelial cells of the capillary wall, astrocyte end-feet ensheathing the capillary, and pericytes embedded in the capillary basement membrane.
When is the blood-brain barrier formed?
Anatomy and Physiology of the Blood–Brain Barrier Formation of BBB occurs during embryonic life and is completed before birth. Most of the properties and complete BBB function, including blockage of systemic dye entrance to brain tissue, is established around the 15th day of embryonic life.
What is the role of the meninges?
The primary function commonly attributed to meninges and CSF is to protect the central nervous system (CNS). This is mainly because meninges provide a tight anchoring of the CNS to the surrounding bones able to prevent side-to-side movement and providing stability.
How are meninges linked to each other?
The two dural layers are firmly attached to each other, except in places where they separate to enclose the dural venous sinuses. In these places, the meningeal layer projects inward, towards the cerebral tissue, forming the fibrous septa that partially separate the cranial cavity.
Which of the following is not a component of blood-brain barrier?
The meninges are three membranes that cover the brain and the spinal cord, and do not contribute to the blood-brain barrier. Endothelial cells, tight junctions, astrocytes, and basement membranes are essential components of the blood-brain barrier that regulate the movement of molecules from the blood into the brain.