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Currently, there are eight FDA-approved NRTIs: abacavir (ABC, Ziagen), didanosine (ddI, Videx), emtricitabine (FTC, Emtriva), lamivudine (3TC, Epivir), stavudine (d4T, Zerit), zalcitabine (ddC, Hivid), zidovudine (AZT, Retrovir), and Tenofovir disoprovil fumarate (TDF, Viread), a nucleotide RT inhibitor (Fig.
What are the 6 classes of antiretroviral drugs (ARDs) for pediatric HIV infection?
- Nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs)
- Nonnucleoside reverse transcriptase inhibitors (NNRTIs)
- Protease inhibitors (PIs)
- Integrase inhibitors (IIs)
- Fusion inhibitors (FIs)
- Chemokine receptor antagonists (CRAs)
What are the three active antiretrovirals?
Most HAART regimens include drugs from at least two of the three classes of antiretroviral therapy (nucleoside analog reverse transcriptase (RT) inhibitors, non-nucleoside analog RT inhibitors, and protease inhibitors).
There are more than 30 antiretroviral medications in six drug classes; these are listed below. Each class of drug attacks HIV in a different way.
Antiretroviral treatment (also known as antiretroviral therapy or ART) are the drugs that treat HIV. Taking ART means that people living with HIV can live long and healthy lives. ART is not a cure for HIV, but it keeps HIV under control, so it doesn’t affect your health and you can carry on with life as usual.
What is the difference between HAART and cART?
1 While combination HIV therapies have historically been referred to as HAART (highly active antiretroviral therapy), the terminology has evolved to where many people simply described it as cART or ART (antiretroviral therapy).
What does HAART consist of?
HAART is a customized combination of different classes of medications that a physician prescribes based on such factors as the patient’s viral load (how much virus is in the blood), the particular strain of the virus, the CD4+ cell count, and other considerations (e.g., disease symptoms).
What do protease inhibitors target?
Protease inhibitors interfere with HIV’s ability to make new viruses inside the CD4 cells. Specifically, they block an enzyme known as protease. Protease breaks down HIV proteins, using those smaller particles to make new viruses that can mature and spread.