Table of Contents
Which is a frameshift mutation substitution nonsense silent or deletion?
A silent mutation occurs when a mutation does not change the amino acid coded for by that codon. A frameshift mutation is an insertion or deletion that changes the reading frame of the entire protein and can have severe detrimental effects. A radioactive mutation is not a specific classification of mutations.
Which is a frameshift mutation substitution?
A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three.
Are frameshift mutations silent?
“Silent” mutation: does not change an amino acid, but in some cases can still have a phenotypic effect, e.g., by speeding up or slowing down protein synthesis, or by affecting splicing. Frameshift mutation: Deletion or insertion of a number of bases that is not a multiple of 3.
What are the three types of frameshift mutations?
Insertions, deletions, and duplications can all be frameshift variants. Some regions of DNA contain short sequences of nucleotides that are repeated a number of times in a row.
What is a frameshift deletion mutation?
A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three.
What type of mutation is nonsense?
A nonsense mutation, or its synonym, a stop mutation, is a change in DNA that causes a protein to terminate or end its translation earlier than expected. This is a common form of mutation in humans and in other animals that causes a shortened or nonfunctional protein to be expressed.
What is frameshift deletion?
Deletion frameshift mutation, wherein one or more nucleotides are deleted in a nucleic acid, resulting in the alteration of the reading frame, i.e., reading frameshift, of the nucleic acid. Deletion is a more common mechanism for inducing the frameshift mutation that results in an altered reading frame.
What are frameshift missense nonsense and silent mutations?
Missense mutations may retain function, depending on the chemistry of the new amino acid and its location in the protein. Nonsense mutations produce truncated and frequently nonfunctional proteins. A frameshift mutation results from an insertion or deletion of a number of nucleotides that is not a multiple of three.
What is a nonsense substitution mutation?
Nonsense Mutation A nonsense mutation is the substitution of a single base pair that leads to the appearance of a stop codon where previously there was a codon specifying an amino acid. The presence of this premature stop codon results in the production of a shortened, and likely nonfunctional, protein.
What is meant by nonsense mutation?
A nonsense mutation is a genetic mutation in a DNA sequence that results in a shorter, unfinished protein product. DNA is a chain of many smaller molecules called nucleotides.
What is nonsense coding?
Stop codons are also called nonsense codons because they do not code for an amino acid and instead signal the end of protein synthesis. Thus, nonsense mutations occur when a premature nonsense or stop codon is introduced in the DNA sequence.
Which one of the following is a nonsense codon?
The three nonsense codons are UAG (amber), UAA (ochre), and UAG (opal). A mutation which replaces a codon for an amino acid with a codon for chain termination (UAG, UAA, or UGA). A mutant tRNA that recognizes a nonsense (stop) codon and inserts an amino acid into the growing polypeptide chain.