Table of Contents
- 1 Why are thiazide diuretics particularly suited to the treatment of hypertension?
- 2 What is the difference between thiazide and loop diuretics?
- 3 How does a thiazide diuretic work?
- 4 What is a thiazide diuretic drug?
- 5 What are the benefits of using diuretic treatment for high blood pressure?
- 6 What is the difference between thiazide and furosemide?
- 7 How do thiazides affect diabetes?
- 8 Why do thiazide diuretics decrease GFR?
- 9 How does diabetes insipidus compare with SIADH?
- 10 Can you take diuretics with diabetes?
Why are thiazide diuretics particularly suited to the treatment of hypertension?
With this inhibition, more sodium stays within the nephron creating an osmotic force that allows for water retention in the nephron, and ultimately water excretion. Thiazide diuretics are considered the drug of choice for long term treatment of hypertension by many physicians.
What is the difference between thiazide and loop diuretics?
They may also be used with antihypertensive drugs to control high blood pressure (hypertension). Lasix is an anthranilic acid derivative that is a type of loop diuretic while thiazides are another class of diuretic. A difference is that loop diuretics are more potent than thiazides.
Can thiazide diuretics be used in diabetic patients?
Recent systematic reviews have concluded that available evidence supported the use of any major class of antihypertensive drugs, including thiazides, for the treatment of hypertensive patients with type 2 diabetes mellitus.
How does a thiazide diuretic work?
Thiazide diuretics work by blocking sodium and chloride (Na/Cl) channels in the distal convoluted tubule of the nephron and inhibit the reabsorption of sodium and water. This also causes a loss of potassium and calcium ions.
What is a thiazide diuretic drug?
Thiazide diuretics are a common treatment for high blood pressure (hypertension). They are also used to clear fluid from the body in conditions where your body accumulates too much fluid, such as heart failure. (However, a type of diuretic called a loop diuretic is more commonly used to treat heart failure.)
What are the benefits of thiazides?
What are the benefits of using diuretic treatment for high blood pressure?
Diuretics, sometimes called water pills, help rid your body of salt (sodium) and water. Most of these medicines help your kidneys release more sodium into your urine. The sodium helps remove water from your blood, decreasing the amount of fluid flowing through your veins and arteries. This reduces blood pressure.
What is the difference between thiazide and furosemide?
Lasix and thiazides are different types of diuretics. Lasix is a type of “loop” diuretic while thiazides refer to a class of diuretics. Lasix is a brand name for furosemide. Examples of thiazide diuretics include chlorthalidone (Thalitone), hydrochlorothiazide (Microzide), and methyclothiazide.
How do thiazide diuretics cause diabetes?
The exact mechanism of how thiazide diuretics cause the development of hyperglycemia is unknown. However, it is postulated to involve worsening of insulin resistance, inhibition of glucose uptake, and decreased insulin release, among other pathways.
How do thiazides affect diabetes?
Prolonged thiazide diuretic therapy can lead to glucose intolerance and may occasionally precipitate diabetes mellitus. Short-term metabolic studies, epidemiologic studies, and a variety of clinical trials suggest a connection between ongoing thiazide diuretic use and the development of type 2 diabetes.
Why do thiazide diuretics decrease GFR?
The traditional thinking is that thiazide-induced blockade of the Na-Cl cotransporter in the distal tubule leads to a decrease in GFR. This decrease is compensated by an increase in proximal tubule sodium and water uptake.
Which drugs can cause diabetes insipidus (DI)?
Lithium is the most common medication that causes diabetes insipidus. This is because it affects the flow of sodium through the muscle and nerve cells in the body. It is often used to treat bipolar disorder, especially if an individual suffers from periodic episodes of mania.
How does diabetes insipidus compare with SIADH?
Diabetes insipidus doesn’t produce enough ADH or respond to it, thus produces too much urine. SIADH is the opposite and retains too much water, rather than excreting it excessively in DI.
Can you take diuretics with diabetes?
It’s important to note that just because a medicine has the possibility of raising blood sugar, it does not mean the medicine is unsafe for a person with diabetes. For instance, many people with type 2 diabetes need to take a diuretic and a statin to lower blood pressure and cholesterol.
What are alternative treatments for diabetes?
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