Table of Contents
What does the AhR gene do?
In addition to regulating metabolism enzymes, the AhR has roles in regulating immunity, stem cell maintenance, and cellular differentiation. The aryl hydrocarbon receptor is a member of the family of basic helix-loop-helix transcription factors.
What is AhR pathway?
The AhR genomic pathway. When a ligand crosses the plasma membrane (passive diffusion), it binds to the AhR (the PAS B domain). This allows the translocation of the ligand-receptor complex into the nucleus and the dissociation of the receptor complex.
Where is AhR located?
Protein domains found in the aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT). The nuclear localization sequence (NLS) and nuclear export sequence (NES) are found within the basic helix loop helix (bHLH) region.
What is AHR activation?
AhR activation upregulates the mRNA expression of its target genes CYP1A1 and CYP1B1 and promotes invasion by upregulating the mRNA expression of MMP-1, MMP-2 and MMP-9 and downregulating the mRNA expression of E-cadherin in human RCC cell lines, including 786-O and ACHN .
What is AHR antagonist?
AHR (Aryl-hydrocarbon receptor; also bHLHE76) is a 110 kDa member of the bHLH/PAS transcription factor family. It is widely expressed (breast, lung, liver), and serves many functions. First, it binds multiple xenobiotic chemicals in the cytoplasm.
Is Ahr a gene?
AHR (Aryl Hydrocarbon Receptor) is a Protein Coding gene. Diseases associated with AHR include Retinitis Pigmentosa 85 and Retinitis Pigmentosa. Among its related pathways are Innate Lymphoid Cells Differentiation and Metapathway biotransformation.
How long is the Ahr River?
What is an AHR agonist?
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important functions in the immune response and cancer. AHR agonists are provided by the environment, the commensal flora and the metabolism.
What river in Germany overflowed?
The Elbe floods alone claimed 20 lives and caused damage totaling more than EUR 9 billion (24). In 2005 floods caused a lot of damage and several casualties in the Alpine region.
Where is the Eifel in Germany?
Eifel, plateau region of western Germany, lying between the Rhine and Mosel (French: Moselle) rivers and the Luxembourg and Belgian frontiers.
What are AHR ligands?
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; commonly referred to as ‘dioxin’).
Why does Amsterdam not flood?
River dikes prevent flooding from water flowing into the country by the major rivers Rhine and Meuse, while a complicated system of drainage ditches, canals, and pumping stations (historically: windmills) keep the low-lying parts dry for habitation and agriculture.